| Platinum | Platinum Trophy | Unlocked all trophies | 2.1% Ultra Rare | 769 pts |
| Gold | I Chose the Impossible | Complete the game on Survivor difficulty without using a Vita-chamber | 2.4% Ultra Rare | 355 pts |
| Gold | Brass Balls | Complete the game on Hard difficulty without using a Vita-Chamber. | 2.6% Ultra Rare | 338 pts |
| Silver | Historian | Find every audio diary | 2.6% Ultra Rare | 254 pts |
| Gold | A Man Chooses | Complete the game on Survivor difficulty | 2.9% Ultra Rare | 317 pts |
| Bronze | Research PhD | Max out all possible research | 3.6% Ultra Rare | 139 pts |
| Bronze | Avid Inventor | Successfully invent at least 100 items | 5.1% Very Rare | 113 pts |
| Bronze | Seriously Good at This | The player has completed the game on the Hard difficulty setting | 5.1% Very Rare | 113 pts |
| Bronze | Weapon Specialist | Acquire all upgrades for all weapons | 5.5% Very Rare | 108 pts |
| Bronze | Fully Researched Bouncer | Fully research the Bouncer | 5.7% Very Rare | 106 pts |
| Bronze | Lucky Winner | Hit the jackpot at a slot machine | 5.7% Very Rare | 106 pts |
| Bronze | Fully Researched Nitro Splicer | Fully research the Nitro Splicer | 6.2% Very Rare | 100 pts |
| Bronze | Fully Researched Little Sister | Fully research the Little Sister | 6.5% Very Rare | 98 pts |
| Bronze | Found Cohen's Room | The player has entered Sander Cohen's personal quarters | 7.6% Very Rare | 89 pts |
| Bronze | Fully Researched Rosie | Fully research the Rosie | 7.7% Very Rare | 88 pts |
| Bronze | Fully Researched Houdini Splicer | Fully research the Houdini Splicer | 8% Very Rare | 86 pts |
| Bronze | Irony | The player has taken a picture of Sander Cohen's corpse | 9.5% Very Rare | 78 pts |
| Bronze | Prolific Photographer | Take at least one photo in every research group | 10.8% Rare | 72 pts |
| Bronze | Five Fully Upgraded Weapons | Fully upgrade five weapons | 10.8% Rare | 72 pts |
| Bronze | Fully Researched Spider Splicer | The player has fully researched the Spider Splicer | 11.2% Rare | 70 pts |
| Bronze | Fully Researched Thug Splicer | The player has fully researched the Thuggish Splicer | 11.5% Rare | 69 pts |
| Bronze | Fully Researched Gun Splicer | The player has fully researched the Leadhead Splicer | 12.9% Rare | 65 pts |
| Bronze | Maxed All Tracks | Purchased every slot in all four Plasmid and Tonic tracks | 14.9% Rare | 59 pts |
| Bronze | Tonic Collector | Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks | 15.1% Rare | 59 pts |
| Bronze | Ammo Inventor | The player has successfully invented all possible ammo types | 15.4% Rare | 58 pts |
| Bronze | Dealt with every Little Sister | The player has either Harvested or Rescued every possible Little Sister | 16.6% Rare | 56 pts |
| Bronze | Four Fully Upgraded Weapons | Fully upgrade four weapons | 17% Rare | 55 pts |
| Silver | Little Sister Savior | The player has completed the game without harvesting any Little Sisters | 19.4% Rare | 76 pts |
| Bronze | Three Fully Upgraded Weapons | The player has fully upgraded three weapons | 23.1% Uncommon | 46 pts |
| Bronze | Defeated Atlas | The player has defeated Atlas | 25.5% Uncommon | 43 pts |
| Bronze | Became a Big Daddy | The player has become a Big Daddy | 26.3% Uncommon | 42 pts |
| Bronze | Skilled Hacker | The player has successfully completed 50 hacks | 26.9% Uncommon | 42 pts |
| Bronze | Broke Fontaine's Mind Control | The player has broken Fontaine's mind control | 27.3% Uncommon | 41 pts |
| Bronze | Two Fully Upgraded Weapons | The player has fully upgraded two weapons | 27.5% Uncommon | 41 pts |
| Bronze | Maxed One Track | The player has purchased every slot in one of the Plasmid or Tonic tracks | 28.4% Uncommon | 40 pts |
| Bronze | Defeated Andrew Ryan | The player has defeated Andrew Ryan | 28.9% Uncommon | 40 pts |
| Bronze | Completed Cohen's Masterpiece | The player has completed Sander Cohen's great masterpiece | 30.8% Uncommon | 38 pts |
| Bronze | One Fully Upgraded Weapon | The player has fully upgraded one weapon | 32.2% Uncommon | 37 pts |
| Bronze | Restored the Forest | The player has restored the forests of Arcadia | 34.6% Uncommon | 36 pts |
| Bronze | Basic Inventor | The player has successfully invented at least one item | 38.8% Uncommon | 33 pts |
| Bronze | Upgraded a Weapon | The player has acquired at least one weapon upgrade | 41.6% Common | 32 pts |
| Bronze | Hacked a Security Camera | The player has successfully hacked a security camera | 41.9% Common | 32 pts |
| Bronze | Defeated Peach Wilkins | The player has defeated Peach Wilkins | 42.1% Common | 32 pts |
| Bronze | Quality Research Photo | The player has taken a Research Photo of the highest grade | 42.8% Common | 32 pts |
| Bronze | Researched a Splicer | The player has taken at least one Research Photo of a Splicer | 46.1% Common | 30 pts |
| Bronze | Bought One Slot | The player has purchased one slot in any Plasmid or Tonic track | 47.1% Common | 30 pts |
| Bronze | Hacked a Turret | The player has successfully hacked a turret | 54.5% Common | 27 pts |
| Bronze | Hacked a Safe | The player has successfully hacked a safe | 55.7% Common | 27 pts |
| Bronze | Defeated Dr. Steinman | The player has defeated the crazed Dr. Steinman | 57.7% Common | 26 pts |
| Bronze | Hacked a Vending Machine | The player has successfully hacked a vending machine | 59.6% Common | 26 pts |
| Bronze | One Successful Hack | The player has performed at least one successful hack | 76.5% Common | 22 pts |
| Bronze | Hacked a Security Bot | The player has successfully hacked a security bot | 76.5% Common | 22 pts |
| Bronze | Completed Welcome | The player has successfully completed the Welcome To Rapture Level | 78.7% Common | 22 pts |
| Bronze | Toaster in the Tub | The player has shocked an enemy in the water | 79.9% Common | 22 pts |