| Platinum | Platinum Trophy | Unlocked all trophies | 3.9% Ultra Rare | 530 pts |
| Gold | I Chose the Impossible | Complete the game on Survivor difficulty without using a Vita-chamber | 4.2% Ultra Rare | 254 pts |
| Gold | Brass Balls | Complete the game on Hard difficulty without using a Vita-Chamber. | 4.5% Ultra Rare | 243 pts |
| Silver | Historian | Find every audio diary | 4.5% Ultra Rare | 183 pts |
| Gold | A Man Chooses | Complete the game on Survivor difficulty | 4.6% Ultra Rare | 240 pts |
| Bronze | Research PhD | Max out all possible research | 5.3% Very Rare | 110 pts |
| Bronze | Avid Inventor | Successfully invent at least 100 items | 5.6% Very Rare | 107 pts |
| Bronze | Seriously Good at This | The player has completed the game on the Hard difficulty setting | 5.9% Very Rare | 103 pts |
| Bronze | Lucky Winner | Hit the jackpot at a slot machine | 7.7% Very Rare | 88 pts |
| Bronze | Fully Researched Bouncer | Fully research the Bouncer | 7.8% Very Rare | 87 pts |
| Bronze | Weapon Specialist | Acquire all upgrades for all weapons | 7.8% Very Rare | 87 pts |
| Bronze | Fully Researched Nitro Splicer | Fully research the Nitro Splicer | 7.9% Very Rare | 87 pts |
| Bronze | Fully Researched Little Sister | Fully research the Little Sister | 9.3% Very Rare | 79 pts |
| Bronze | Fully Researched Houdini Splicer | Fully research the Houdini Splicer | 10.6% Rare | 73 pts |
| Bronze | Fully Researched Rosie | Fully research the Rosie | 10.6% Rare | 73 pts |
| Bronze | Found Cohen's Room | The player has entered Sander Cohen's personal quarters | 11.1% Rare | 71 pts |
| Bronze | Ammo Inventor | The player has successfully invented all possible ammo types | 12.6% Rare | 66 pts |
| Bronze | Prolific Photographer | Take at least one photo in every research group | 12.9% Rare | 65 pts |
| Bronze | Five Fully Upgraded Weapons | Fully upgrade five weapons | 13.2% Rare | 64 pts |
| Bronze | Irony | The player has taken a picture of Sander Cohen's corpse | 14.7% Rare | 60 pts |
| Bronze | Fully Researched Spider Splicer | The player has fully researched the Spider Splicer | 15.3% Rare | 58 pts |
| Bronze | Fully Researched Thug Splicer | The player has fully researched the Thuggish Splicer | 15.8% Rare | 57 pts |
| Bronze | Fully Researched Gun Splicer | The player has fully researched the Leadhead Splicer | 17.2% Rare | 54 pts |
| Bronze | Tonic Collector | Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks | 18.9% Rare | 51 pts |
| Bronze | Maxed All Tracks | Purchased every slot in all four Plasmid and Tonic tracks | 19.7% Rare | 50 pts |
| Bronze | Four Fully Upgraded Weapons | Fully upgrade four weapons | 19.7% Rare | 50 pts |
| Bronze | Dealt with every Little Sister | The player has either Harvested or Rescued every possible Little Sister | 20% Uncommon | 50 pts |
| Silver | Little Sister Savior | The player has completed the game without harvesting any Little Sisters | 21.9% Uncommon | 71 pts |
| Bronze | Three Fully Upgraded Weapons | The player has fully upgraded three weapons | 24.7% Uncommon | 44 pts |
| Bronze | Defeated Atlas | The player has defeated Atlas | 26% Uncommon | 42 pts |
| Bronze | Became a Big Daddy | The player has become a Big Daddy | 26.6% Uncommon | 42 pts |
| Bronze | Broke Fontaine's Mind Control | The player has broken Fontaine's mind control | 27.3% Uncommon | 41 pts |
| Bronze | Two Fully Upgraded Weapons | The player has fully upgraded two weapons | 28% Uncommon | 41 pts |
| Bronze | Defeated Andrew Ryan | The player has defeated Andrew Ryan | 28.8% Uncommon | 40 pts |
| Bronze | Maxed One Track | The player has purchased every slot in one of the Plasmid or Tonic tracks | 29.3% Uncommon | 40 pts |
| Bronze | Completed Cohen's Masterpiece | The player has completed Sander Cohen's great masterpiece | 30.4% Uncommon | 39 pts |
| Bronze | Skilled Hacker | The player has successfully completed 50 hacks | 30.7% Uncommon | 38 pts |
| Bronze | One Fully Upgraded Weapon | The player has fully upgraded one weapon | 31.7% Uncommon | 38 pts |
| Bronze | Restored the Forest | The player has restored the forests of Arcadia | 33.9% Uncommon | 36 pts |
| Bronze | Basic Inventor | The player has successfully invented at least one item | 37% Uncommon | 34 pts |
| Bronze | Upgraded a Weapon | The player has acquired at least one weapon upgrade | 39.6% Uncommon | 33 pts |
| Bronze | Defeated Peach Wilkins | The player has defeated Peach Wilkins | 39.9% Uncommon | 33 pts |
| Bronze | Hacked a Security Camera | The player has successfully hacked a security camera | 40.1% Common | 33 pts |
| Bronze | Quality Research Photo | The player has taken a Research Photo of the highest grade | 40.8% Common | 32 pts |
| Bronze | Researched a Splicer | The player has taken at least one Research Photo of a Splicer | 42.8% Common | 32 pts |
| Bronze | Bought One Slot | The player has purchased one slot in any Plasmid or Tonic track | 44% Common | 31 pts |
| Bronze | Hacked a Safe | The player has successfully hacked a safe | 52.1% Common | 28 pts |
| Bronze | Defeated Dr. Steinman | The player has defeated the crazed Dr. Steinman | 52.2% Common | 28 pts |
| Bronze | Hacked a Turret | The player has successfully hacked a turret | 54.3% Common | 27 pts |
| Bronze | Hacked a Vending Machine | The player has successfully hacked a vending machine | 56.9% Common | 27 pts |
| Bronze | Hacked a Security Bot | The player has successfully hacked a security bot | 70.1% Common | 23 pts |
| Bronze | One Successful Hack | The player has performed at least one successful hack | 70.2% Common | 23 pts |
| Bronze | Completed Welcome | The player has successfully completed the Welcome To Rapture Level | 73% Common | 23 pts |
| Bronze | Toaster in the Tub | The player has shocked an enemy in the water | 75% Common | 22 pts |