| Platinum | Platinum Trophy | Unlocked all trophies | 1.9% Ultra Rare | 816 pts |
| Gold | I Chose the Impossible | Complete the game on Survivor difficulty without using a Vita-chamber | 2.1% Ultra Rare | 384 pts |
| Gold | Brass Balls | Complete the game on Hard difficulty without using a Vita-Chamber. | 2.2% Ultra Rare | 374 pts |
| Silver | Historian | Find every audio diary | 2.2% Ultra Rare | 280 pts |
| Gold | A Man Chooses | Complete the game on Survivor difficulty | 2.4% Ultra Rare | 355 pts |
| Bronze | Research PhD | Max out all possible research | 2.7% Ultra Rare | 165 pts |
| Bronze | Seriously Good at This | The player has completed the game on the Hard difficulty setting | 3.3% Ultra Rare | 147 pts |
| Bronze | Avid Inventor | Successfully invent at least 100 items | 3.7% Ultra Rare | 137 pts |
| Bronze | Weapon Specialist | Acquire all upgrades for all weapons | 3.8% Ultra Rare | 135 pts |
| Bronze | Fully Researched Bouncer | Fully research the Bouncer | 3.8% Ultra Rare | 135 pts |
| Bronze | Fully Researched Nitro Splicer | Fully research the Nitro Splicer | 4.1% Ultra Rare | 129 pts |
| Bronze | Lucky Winner | Hit the jackpot at a slot machine | 4.1% Ultra Rare | 129 pts |
| Bronze | Fully Researched Little Sister | Fully research the Little Sister | 4.2% Ultra Rare | 127 pts |
| Bronze | Fully Researched Rosie | Fully research the Rosie | 5% Very Rare | 114 pts |
| Bronze | Fully Researched Houdini Splicer | Fully research the Houdini Splicer | 5.1% Very Rare | 113 pts |
| Bronze | Found Cohen's Room | The player has entered Sander Cohen's personal quarters | 5.1% Very Rare | 113 pts |
| Bronze | Irony | The player has taken a picture of Sander Cohen's corpse | 6.8% Very Rare | 95 pts |
| Bronze | Fully Researched Spider Splicer | The player has fully researched the Spider Splicer | 7.1% Very Rare | 93 pts |
| Bronze | Prolific Photographer | Take at least one photo in every research group | 7.1% Very Rare | 93 pts |
| Bronze | Five Fully Upgraded Weapons | Fully upgrade five weapons | 7.3% Very Rare | 91 pts |
| Bronze | Fully Researched Thug Splicer | The player has fully researched the Thuggish Splicer | 7.4% Very Rare | 90 pts |
| Bronze | Fully Researched Gun Splicer | The player has fully researched the Leadhead Splicer | 8.4% Very Rare | 84 pts |
| Bronze | Tonic Collector | Collect or Invent 58 Tonics in the Physical, Engineering and Combat tracks | 10.1% Rare | 75 pts |
| Bronze | Maxed All Tracks | Purchased every slot in all four Plasmid and Tonic tracks | 10.2% Rare | 74 pts |
| Bronze | Ammo Inventor | The player has successfully invented all possible ammo types | 10.7% Rare | 72 pts |
| Bronze | Dealt with every Little Sister | The player has either Harvested or Rescued every possible Little Sister | 10.7% Rare | 72 pts |
| Bronze | Four Fully Upgraded Weapons | Fully upgrade four weapons | 11.7% Rare | 69 pts |
| Silver | Little Sister Savior | The player has completed the game without harvesting any Little Sisters | 12.9% Rare | 97 pts |
| Bronze | Three Fully Upgraded Weapons | The player has fully upgraded three weapons | 16.1% Rare | 57 pts |
| Bronze | Skilled Hacker | The player has successfully completed 50 hacks | 17.5% Rare | 54 pts |
| Bronze | Defeated Atlas | The player has defeated Atlas | 17.5% Rare | 54 pts |
| Bronze | Became a Big Daddy | The player has become a Big Daddy | 18.1% Rare | 53 pts |
| Bronze | Broke Fontaine's Mind Control | The player has broken Fontaine's mind control | 19% Rare | 51 pts |
| Bronze | Two Fully Upgraded Weapons | The player has fully upgraded two weapons | 19.4% Rare | 51 pts |
| Bronze | Maxed One Track | The player has purchased every slot in one of the Plasmid or Tonic tracks | 19.9% Rare | 50 pts |
| Bronze | Defeated Andrew Ryan | The player has defeated Andrew Ryan | 20.2% Uncommon | 49 pts |
| Bronze | Completed Cohen's Masterpiece | The player has completed Sander Cohen's great masterpiece | 21.7% Uncommon | 47 pts |
| Bronze | One Fully Upgraded Weapon | The player has fully upgraded one weapon | 23.1% Uncommon | 46 pts |
| Bronze | Restored the Forest | The player has restored the forests of Arcadia | 24.7% Uncommon | 44 pts |
| Bronze | Basic Inventor | The player has successfully invented at least one item | 28.2% Uncommon | 40 pts |
| Bronze | Hacked a Security Camera | The player has successfully hacked a security camera | 29.1% Uncommon | 40 pts |
| Bronze | Upgraded a Weapon | The player has acquired at least one weapon upgrade | 30.9% Uncommon | 38 pts |
| Bronze | Defeated Peach Wilkins | The player has defeated Peach Wilkins | 31.1% Uncommon | 38 pts |
| Bronze | Quality Research Photo | The player has taken a Research Photo of the highest grade | 31.7% Uncommon | 38 pts |
| Bronze | Researched a Splicer | The player has taken at least one Research Photo of a Splicer | 34.9% Uncommon | 36 pts |
| Bronze | Bought One Slot | The player has purchased one slot in any Plasmid or Tonic track | 35.7% Uncommon | 35 pts |
| Bronze | Hacked a Turret | The player has successfully hacked a turret | 41.2% Common | 32 pts |
| Bronze | Hacked a Safe | The player has successfully hacked a safe | 43.4% Common | 31 pts |
| Bronze | Defeated Dr. Steinman | The player has defeated the crazed Dr. Steinman | 45.7% Common | 30 pts |
| Bronze | Hacked a Vending Machine | The player has successfully hacked a vending machine | 46.4% Common | 30 pts |
| Bronze | Hacked a Security Bot | The player has successfully hacked a security bot | 65.8% Common | 24 pts |
| Bronze | One Successful Hack | The player has performed at least one successful hack | 66.2% Common | 24 pts |
| Bronze | Completed Welcome | The player has successfully completed the Welcome To Rapture Level | 68.1% Common | 24 pts |
| Bronze | Toaster in the Tub | The player has shocked an enemy in the water | 70.1% Common | 23 pts |