| Platinum | Platinum Trophy | Unlocked all trophies | 2.9% Ultra Rare | 633 pts |
| Gold | Against All Odds | Finished the game on the hardest difficulty level. | 4.5% Ultra Rare | 243 pts |
| Bronze | Research Master | Completed all research on every subject in Rapture. | 4.5% Ultra Rare | 122 pts |
| Bronze | 9-Irony | Paid your respects to the founder of Rapture. | 4.7% Ultra Rare | 119 pts |
| Bronze | All Plasmids | Found or purchased all 11 basic Plasmid types. | 6.4% Very Rare | 98 pts |
| Silver | All Weapon Upgrades | Found every Power to the People weapon upgrade in the game. | 7.3% Very Rare | 137 pts |
| Gold | Big Brass Balls | Finished the game without using Vita-Chambers. | 7.6% Very Rare | 178 pts |
| Silver | Savior | Saved every Little Sister and spared Grace, Stanley and Gil. | 10.2% Rare | 112 pts |
| Silver | Rapture Historian | Found 100 audio diaries. | 12.1% Rare | 101 pts |
| Bronze | Master Protector | Got through a Gather with no damage and no one getting to the Little Sister. | 12.1% Rare | 67 pts |
| Bronze | One Research Track | Maxed out one Research Track. | 12.7% Rare | 65 pts |
| Bronze | Counterattack | Killed an enemy with its own projectile. | 17.7% Rare | 54 pts |
| Bronze | Trap Master | Killed 30 enemies using only Traps. | 18% Rare | 53 pts |
| Bronze | Master Hacker | Hacked 30 machines at a distance with the Hack Tool. | 20.5% Uncommon | 49 pts |
| Bronze | Look at You, Hacker | Killed 50 enemies using only hacked Security. | 20.9% Uncommon | 48 pts |
| Bronze | Max Plasmid Slots | Fully upgraded to the maximum number of Plasmid Slots. | 21.5% Uncommon | 48 pts |
| Silver | Master Gatherer | Gathered 600 ADAM with Little Sisters. | 22.7% Uncommon | 69 pts |
| Silver | Dealt with Every Little Sister | Dealt with every Little Sister. | 22.8% Uncommon | 69 pts |
| Gold | Escape | Escaped Rapture. | 26.2% Uncommon | 85 pts |
| Bronze | Heading to the Surface | Headed to the surface on the side of Sinclair's escape pod. | 26.2% Uncommon | 42 pts |
| Bronze | Fully Upgraded a Plasmid | Fully upgraded one Plasmid to the Level 3 version. | 26.4% Uncommon | 42 pts |
| Silver | Reunion | Reunited with your original Little Sister. | 26.9% Uncommon | 62 pts |
| Bronze | Found Lamb's Hideout | Gained access to Lamb's stronghold. | 27.1% Uncommon | 41 pts |
| Silver | Nose for News | Uncovered the secret of Dionysus Park. | 29.1% Uncommon | 60 pts |
| Silver | Grand Daddy | Defeated 3 Big Daddies without dying during the fight. | 29.4% Uncommon | 59 pts |
| Bronze | Fully Upgraded a Weapon | Installed the third upgrade to a weapon. | 31% Uncommon | 38 pts |
| Bronze | Defeated the Preacher | Defeated the Preacher. | 31.6% Uncommon | 38 pts |
| Bronze | Big Spender | Spent 2000 dollars at Vending Machines. | 34.3% Uncommon | 36 pts |
| Bronze | Confronted Grace | Confronted Lamb's lieutenant in Pauper's Drop. | 35.6% Uncommon | 35 pts |
| Bronze | Unbreakable | Defended yourself against the Big Sister without dying. | 35.8% Uncommon | 35 pts |
| Gold | Bought a Slot | Bought one Plasmid or Tonic Slot at a Gatherer's Garden. | 36.9% Uncommon | 69 pts |
| Bronze | Prolific Hacker | Hacked one of each kind of machine. | 36.9% Uncommon | 34 pts |
| Bronze | First Research | Researched a Splicer with the Research Camera. | 37.8% Uncommon | 34 pts |
| Silver | Sinclair's Solution | Joined forces with Sinclair in Ryan Amusements. | 41.1% Common | 48 pts |
| Bronze | Adopted a Little Sister | Adopted a new Little Sister for the very first time. | 46.9% Common | 30 pts |
| Bronze | Upgraded a Weapon | Upgraded a weapon at a Power to the People Station. | 48.4% Common | 29 pts |
| Bronze | Protector | Defended yourself against Lamb's Assault in the train station. | 50.9% Common | 28 pts |
| Bronze | Distance Hacker | Used the Hack Tool to hack an object at a distance. | 67.3% Common | 24 pts |
| Bronze | Daddy's Home | Found your way back into the ruins of Rapture. | 70.9% Common | 23 pts |