| Platinum | Platinum Trophy | Unlocked all trophies | 9.2% Very Rare | 317 pts |
| Bronze | 9-Irony | Paid your respects to the founder of Rapture. | 10.4% Rare | 74 pts |
| Gold | Against All Odds | Finished the game on the hardest difficulty level. | 11.1% Rare | 142 pts |
| Bronze | Research Master | Completed all research on every subject in Rapture. | 12% Rare | 68 pts |
| Bronze | All Plasmids | Found or purchased all 11 basic Plasmid types. | 13.3% Rare | 64 pts |
| Silver | All Weapon Upgrades | Found every Power to the People weapon upgrade in the game. | 16% Rare | 85 pts |
| Gold | Big Brass Balls | Finished the game without using Vita-Chambers. | 16.7% Rare | 111 pts |
| Silver | Savior | Saved every Little Sister and spared Grace, Stanley and Gil. | 22.1% Uncommon | 70 pts |
| Bronze | Master Protector | Got through a Gather with no damage and no one getting to the Little Sister. | 24.5% Uncommon | 44 pts |
| Silver | Rapture Historian | Found 100 audio diaries. | 27.7% Uncommon | 61 pts |
| Bronze | Trap Master | Killed 30 enemies using only Traps. | 28% Uncommon | 41 pts |
| Bronze | Counterattack | Killed an enemy with its own projectile. | 28.3% Uncommon | 40 pts |
| Bronze | One Research Track | Maxed out one Research Track. | 30.4% Uncommon | 39 pts |
| Bronze | Max Plasmid Slots | Fully upgraded to the maximum number of Plasmid Slots. | 34% Uncommon | 36 pts |
| Bronze | Look at You, Hacker | Killed 50 enemies using only hacked Security. | 36.7% Uncommon | 35 pts |
| Bronze | Master Hacker | Hacked 30 machines at a distance with the Hack Tool. | 36.8% Uncommon | 34 pts |
| Silver | Dealt with Every Little Sister | Dealt with every Little Sister. | 39.4% Uncommon | 50 pts |
| Gold | Escape | Escaped Rapture. | 39.7% Uncommon | 66 pts |
| Bronze | Heading to the Surface | Headed to the surface on the side of Sinclair's escape pod. | 39.7% Uncommon | 33 pts |
| Silver | Reunion | Reunited with your original Little Sister. | 40.2% Common | 49 pts |
| Silver | Master Gatherer | Gathered 600 ADAM with Little Sisters. | 40.4% Common | 49 pts |
| Bronze | Found Lamb's Hideout | Gained access to Lamb's stronghold. | 40.5% Common | 33 pts |
| Bronze | Fully Upgraded a Plasmid | Fully upgraded one Plasmid to the Level 3 version. | 41.2% Common | 32 pts |
| Silver | Nose for News | Uncovered the secret of Dionysus Park. | 42.6% Common | 47 pts |
| Bronze | Fully Upgraded a Weapon | Installed the third upgrade to a weapon. | 44.3% Common | 31 pts |
| Bronze | Defeated the Preacher | Defeated the Preacher. | 44.8% Common | 31 pts |
| Silver | Grand Daddy | Defeated 3 Big Daddies without dying during the fight. | 45.1% Common | 46 pts |
| Bronze | Big Spender | Spent 2000 dollars at Vending Machines. | 47.1% Common | 30 pts |
| Bronze | Confronted Grace | Confronted Lamb's lieutenant in Pauper's Drop. | 47.9% Common | 29 pts |
| Bronze | First Research | Researched a Splicer with the Research Camera. | 49.6% Common | 29 pts |
| Gold | Bought a Slot | Bought one Plasmid or Tonic Slot at a Gatherer's Garden. | 49.8% Common | 58 pts |
| Bronze | Prolific Hacker | Hacked one of each kind of machine. | 50.2% Common | 29 pts |
| Bronze | Unbreakable | Defended yourself against the Big Sister without dying. | 51.3% Common | 28 pts |
| Silver | Sinclair's Solution | Joined forces with Sinclair in Ryan Amusements. | 53.3% Common | 41 pts |
| Bronze | Adopted a Little Sister | Adopted a new Little Sister for the very first time. | 57.2% Common | 26 pts |
| Bronze | Upgraded a Weapon | Upgraded a weapon at a Power to the People Station. | 58.4% Common | 26 pts |
| Bronze | Protector | Defended yourself against Lamb's Assault in the train station. | 61.4% Common | 25 pts |
| Bronze | Distance Hacker | Used the Hack Tool to hack an object at a distance. | 72.3% Common | 23 pts |
| Bronze | Daddy's Home | Found your way back into the ruins of Rapture. | 76.2% Common | 22 pts |