| Platinum | Biosplattered | Unlock all trophies. | 1.6% Ultra Rare | 905 pts |
| Silver | Mad Pelicans | Obtain all of the Antique Coins in Madhouse difficulty. | 1.8% Ultra Rare | 316 pts |
| Gold | Resource Manager | Complete the game without opening the Item Box more than 3 times. | 2% Ultra Rare | 396 pts |
| Gold | Walk it Off | Complete the game using only 3 First Aid Meds or less. | 2.2% Ultra Rare | 374 pts |
| Silver | Pelicans in Your Pocket | Obtain all of the Antique Coins in Easy or Normal difficulty. | 2.7% Ultra Rare | 248 pts |
| Silver | Who's Your Daddy Now? | Complete the game on Madhouse. | 2.8% Ultra Rare | 243 pts |
| Silver | The Devil Is in the Details | Read all of the files in a single playthrough. | 3.3% Ultra Rare | 220 pts |
| Silver | Out Before Dessert | Complete the "Happy Birthday" videotape within 5 minutes. | 3.5% Ultra Rare | 212 pts |
| Silver | Mr. Nowhere | Destroy all Mr. Everywhere statuettes. | 3.6% Ultra Rare | 209 pts |
| Gold | Just Get Me Outta Here | Complete the game within 4 hours. | 3.8% Ultra Rare | 269 pts |
| Bronze | That's a Spicy Meat-a-ball | Kill an enemy by attaching a Remote Bomb to them and detonating it. | 6.5% Very Rare | 98 pts |
| Bronze | 1st Place at the Science Fair | Create all items that contain Chem Fluid and Strong Chem Fluid. | 6.7% Very Rare | 96 pts |
| Silver | Just A Memory Now | Get ending 2. | 12.2% Rare | 100 pts |
| Silver | Duck If You Love Life | Avoid Jack's scissor attack by crouching. | 12.2% Rare | 100 pts |
| Silver | Fly Swatter | Shoot and knock back Marguerite while she's leaping at you. | 13.1% Rare | 96 pts |
| Silver | Back Off, Mrs. B! | Fight off Marguerite while she wanders the old house to make her run away. | 14% Rare | 92 pts |
| Bronze | Slash Slash, Slashity Slash! | Clear insects off a door using a knife. | 15.6% Rare | 58 pts |
| Bronze | The Nightmare's Finally Over | Complete the game on Normal. | 22.6% Uncommon | 46 pts |
| Silver | End of the Night | Get ending 1. | 26.7% Uncommon | 63 pts |
| Bronze | Be Kind, Please Rewind | Watch all the videotapes in a single playthrough. | 29% Uncommon | 40 pts |
| Silver | Less is More | Take down two or more enemies with one shot. | 32.6% Uncommon | 56 pts |
| Bronze | Playing it Safe | Complete the game on Easy. | 32.6% Uncommon | 37 pts |
| Bronze | Into the Depths | Escape from the ship. | 33.3% Uncommon | 37 pts |
| Bronze | You Better Start Running | Escape from the Baker family home. | 36.2% Uncommon | 35 pts |
| Bronze | The Grave Will Out the Truth | Uncover the secret in the old house. | 39.4% Uncommon | 33 pts |
| Bronze | In the Bag | Increase your item slots. | 42.6% Common | 32 pts |
| Bronze | You Ain't Gettin' Away | Escape to the yard. | 44% Common | 31 pts |
| Bronze | Open Your Eyes | Use psychostimulants. | 45.9% Common | 30 pts |
| Bronze | Things Got Personal | Finish off an enemy with the knife. | 49.1% Common | 29 pts |
| Bronze | Nice Try | Put an unrelated object on a shadow plinth. | 49.4% Common | 29 pts |
| Bronze | Can't Catch Me | Complete the "Mia" videotape without being spotted by Marguerite. | 49.6% Common | 29 pts |
| Bronze | He's Here, There, Everywhere! | Destroy a Mr. Everywhere statuette. | 55.4% Common | 27 pts |
| Bronze | Master of Unlocking | Use a lock pick to open something. | 57.3% Common | 26 pts |
| Bronze | Arms in the Air | Block an enemy attack by guarding. | 61.6% Common | 25 pts |
| Bronze | Welcome to the Family, Son | Escape from the guest house. | 70.6% Common | 23 pts |
| Bronze | Behind Closed Doors | Close an open door by yourself. | 72.2% Common | 23 pts |
| Bronze | A-ha! | Obtain something by closely examining an item. | 79.1% Common | 22 pts |
| Bronze | She's Alive | Travel to Louisiana. | 89.5% Common | 20 pts |