| Platinum | Biosplattered | Unlock all trophies. | 3.7% Ultra Rare | 547 pts |
| Gold | Resource Manager | Complete the game without opening the Item Box more than 3 times. | 4.4% Ultra Rare | 247 pts |
| Silver | Mad Pelicans | Obtain all of the Antique Coins in Madhouse difficulty. | 4.5% Ultra Rare | 183 pts |
| Gold | Walk it Off | Complete the game using only 3 First Aid Meds or less. | 4.6% Ultra Rare | 240 pts |
| Silver | Pelicans in Your Pocket | Obtain all of the Antique Coins in Easy or Normal difficulty. | 6% Very Rare | 154 pts |
| Silver | Who's Your Daddy Now? | Complete the game on Madhouse. | 6.3% Very Rare | 149 pts |
| Silver | Out Before Dessert | Complete the "Happy Birthday" videotape within 5 minutes. | 6.6% Very Rare | 145 pts |
| Silver | The Devil Is in the Details | Read all of the files in a single playthrough. | 6.7% Very Rare | 144 pts |
| Gold | Just Get Me Outta Here | Complete the game within 4 hours. | 7.6% Very Rare | 178 pts |
| Silver | Mr. Nowhere | Destroy all Mr. Everywhere statuettes. | 7.7% Very Rare | 132 pts |
| Bronze | That's a Spicy Meat-a-ball | Kill an enemy by attaching a Remote Bomb to them and detonating it. | 8.4% Very Rare | 84 pts |
| Bronze | 1st Place at the Science Fair | Create all items that contain Chem Fluid and Strong Chem Fluid. | 10.1% Rare | 75 pts |
| Silver | Just A Memory Now | Get ending 2. | 13.3% Rare | 95 pts |
| Silver | Duck If You Love Life | Avoid Jack's scissor attack by crouching. | 16.7% Rare | 83 pts |
| Silver | Back Off, Mrs. B! | Fight off Marguerite while she wanders the old house to make her run away. | 17.3% Rare | 81 pts |
| Silver | Fly Swatter | Shoot and knock back Marguerite while she's leaping at you. | 18% Rare | 79 pts |
| Bronze | Slash Slash, Slashity Slash! | Clear insects off a door using a knife. | 19.8% Rare | 50 pts |
| Bronze | The Nightmare's Finally Over | Complete the game on Normal. | 34.9% Uncommon | 36 pts |
| Silver | End of the Night | Get ending 1. | 36.8% Uncommon | 52 pts |
| Bronze | Be Kind, Please Rewind | Watch all the videotapes in a single playthrough. | 39.9% Uncommon | 33 pts |
| Silver | Less is More | Take down two or more enemies with one shot. | 42.6% Common | 47 pts |
| Bronze | Playing it Safe | Complete the game on Easy. | 46.9% Common | 30 pts |
| Bronze | Into the Depths | Escape from the ship. | 47.1% Common | 30 pts |
| Bronze | You Better Start Running | Escape from the Baker family home. | 50.2% Common | 29 pts |
| Bronze | In the Bag | Increase your item slots. | 52.1% Common | 28 pts |
| Bronze | Can't Catch Me | Complete the "Mia" videotape without being spotted by Marguerite. | 52.1% Common | 28 pts |
| Bronze | Nice Try | Put an unrelated object on a shadow plinth. | 52.5% Common | 28 pts |
| Bronze | The Grave Will Out the Truth | Uncover the secret in the old house. | 53.5% Common | 28 pts |
| Bronze | Open Your Eyes | Use psychostimulants. | 58% Common | 26 pts |
| Bronze | You Ain't Gettin' Away | Escape to the yard. | 58.1% Common | 26 pts |
| Bronze | Things Got Personal | Finish off an enemy with the knife. | 61% Common | 25 pts |
| Bronze | He's Here, There, Everywhere! | Destroy a Mr. Everywhere statuette. | 67.2% Common | 24 pts |
| Bronze | Master of Unlocking | Use a lock pick to open something. | 69.1% Common | 24 pts |
| Bronze | Arms in the Air | Block an enemy attack by guarding. | 69.6% Common | 24 pts |
| Bronze | Behind Closed Doors | Close an open door by yourself. | 73.6% Common | 23 pts |
| Bronze | Welcome to the Family, Son | Escape from the guest house. | 77.2% Common | 22 pts |
| Bronze | A-ha! | Obtain something by closely examining an item. | 84% Common | 21 pts |
| Bronze | She's Alive | Travel to Louisiana. | 88.6% Common | 20 pts |