| Platinum | From Gloom, to Glory! | Obtain every Trophy in the Main Story | 2.3% Ultra Rare | 243 pts |
| Gold | Savior | Complete the game without killing any Cultists | 2.6% Ultra Rare | 113 pts |
| Gold | Summer Solstice | Complete the game in 4 hours or less | 2.7% Ultra Rare | 110 pts |
| Gold | Bookworm | Find all Lore pickups in the Main Story | 3.5% Ultra Rare | 94 pts |
| Gold | Magister Scientiae | Complete the game on Magister difficulty | 3.6% Ultra Rare | 93 pts |
| Silver | Shh... | Beat the game with Spirit as your highest stat | 4.6% Ultra Rare | 60 pts |
| Silver | Cuisses De Grenouille | Find and kill the hidden Giant Cankertoad | 5.1% Very Rare | 56 pts |
| Silver | Calm Waters | Beat the game with Body as your highest stat | 5.4% Very Rare | 55 pts |
| Silver | Rooted in Reality | Destroy 15 Mandacores | 6.6% Very Rare | 48 pts |
| Bronze | Self-help | Completely upgrade one of the Mind, Body, or Spirit upgrade trees | 8.5% Very Rare | 28 pts |
| Silver | Alchemist | Complete the Alchemical Plant Puzzle without making Alchemical Mulch | 9.7% Very Rare | 38 pts |
| Silver | You have chosen... Wisely | Complete the Rafters puzzle without falling | 13.1% Rare | 32 pts |
| Bronze | Prismic Focus | Use prism abilities 30 times | 18.2% Rare | 18 pts |
| Silver | The Howling Dark | Beat the game with Mind as your highest stat | 26.7% Uncommon | 21 pts |
| Bronze | Purge the Heretics | Defeat 40 Cultists | 26.8% Uncommon | 14 pts |
| Silver | Film Festival | Find all Projector Reels | 30.8% Uncommon | 19 pts |
| Bronze | Thaumaturgy | Craft 30 items | 32.3% Uncommon | 12 pts |
| Bronze | Unmasked | Complete Chapter 5 | 32.4% Uncommon | 12 pts |
| Bronze | Gloom Hunter | Defeat 35 Gloom Creatures | 32.6% Uncommon | 12 pts |
| Bronze | Stalwart Psychosis | Succeed on 20 Mind Attacks | 34.1% Uncommon | 12 pts |
| Silver | Historian | Find 45 Lore pickups | 34.4% Uncommon | 18 pts |
| Bronze | The Ritual | Complete Chapter 4 | 35.8% Uncommon | 12 pts |
| Gold | Friendly Fire | Force an enemy to kill another enemy | 38.5% Uncommon | 22 pts |
| Bronze | Archeologist | Find 25 Lore pickups | 39.4% Uncommon | 11 pts |
| Bronze | Raw Veganism | Consume 30 healing items | 41.1% Common | 11 pts |
| Bronze | Icarus | Complete Chapter 3 | 42.9% Common | 10 pts |
| Bronze | Tools of Consecration | Deplete 20 throwables | 43.4% Common | 10 pts |
| Bronze | Scavenger | Open 15 cabinets | 45.9% Common | 10 pts |
| Bronze | Spelunker | Find 10 Lore pickups | 58.8% Common | 9 pts |
| Bronze | Broken Friendship | Complete Chapter 2 | 63.4% Common | 8 pts |
| Bronze | Light at the End of the Tunnel | Escape to the Cannery | 74.7% Common | 8 pts |
| Bronze | Your Weekend Retreat Begins! | Complete Chapter 1 | 77.1% Common | 7 pts |
| Bronze | The Commencement | It begins... | 79.3% Common | 7 pts |
| Bronze | Resourceful | Collect the resources needed to craft your first weapon | 87% Common | 7 pts |