| Platinum | One Last Time | Collect All The Trophies | 0.6% Ultra Rare | 1,630 pts |
| Silver | Charted! - Speedrun | Complete the game in 6 hours or less | 0.8% Ultra Rare | 514 pts |
| Silver | Peaceful Resolution | After being marooned, leave everyone alive until the Treasury | 0.9% Ultra Rare | 479 pts |
| Bronze | Sharpshooter | Complete game with 70% or higher shot accuracy | 0.9% Ultra Rare | 320 pts |
| Silver | Run the Table | Defeat enemies with a stealth attack, melee attack, headshot, and explosives, in that order, in 15 seconds | 1.2% Ultra Rare | 403 pts |
| Silver | Swordmaster | Perfectly parry Rafe in the sword fight without getting slashed or stabbed | 1.2% Ultra Rare | 403 pts |
| Silver | Gift of Gab | Listen to all optional conversations in game | 1.2% Ultra Rare | 403 pts |
| Bronze | Defeat 10 in 60 -- China Lake GL | Defeat 10 enemies in 60 seconds with the China Lake Grenade Launcher | 1.2% Ultra Rare | 269 pts |
| Bronze | On Porpoise | Get three dolphins to follow the boat | 1.2% Ultra Rare | 269 pts |
| Bronze | Not a Cairn in the World | Knock over all rock cairns in Madagascar | 1.2% Ultra Rare | 269 pts |
| Bronze | Leapfrog | Defeat 10 enemies in a row, alternating gunplay and hand-to-hand | 1.2% Ultra Rare | 269 pts |
| Silver | Treasure Master | Find all Treasures | 1.3% Ultra Rare | 384 pts |
| Bronze | Lost Art of Journaling | Find all Journal Entries | 1.3% Ultra Rare | 256 pts |
| Bronze | Trials by Fire | Complete all trials on Moderate (difficulty) in Multiplayer | 1.3% Ultra Rare | 256 pts |
| Bronze | Lost History | Find All Journal Notes | 1.3% Ultra Rare | 256 pts |
| Silver | Charted! - Crushing | Complete the game in crushing mode | 1.4% Ultra Rare | 368 pts |
| Silver | Ghost in the Cemetery | Get through Scotland cemetery combat encounter without killing or being seen | 1.4% Ultra Rare | 368 pts |
| Bronze | Hangman's Bullet | Perform 20 headshots from the rope | 1.4% Ultra Rare | 245 pts |
| Bronze | I Thought I Heard Something | Perform 30 vertical stealth takedowns | 1.4% Ultra Rare | 245 pts |
| Bronze | Relic Finder | Find the Strange Relics | 1.5% Ultra Rare | 235 pts |
| Bronze | Just Floor It! | Drive away in the jeep with Elena without killing any enemies | 1.5% Ultra Rare | 235 pts |
| Bronze | Best Score! | Beat the best score in the retro videogame | 1.5% Ultra Rare | 235 pts |
| Bronze | I Accidentally All the Guns | Use every weapon in the game | 2.3% Ultra Rare | 182 pts |
| Bronze | Rushing Roulette | Defeat enemies with a pistol, machine gun, and grenade, in that order, in 15 seconds | 2.5% Ultra Rare | 173 pts |
| Bronze | Stage Fright | Just prior to City Chase, stand perfectly still for 30 seconds (stage demo fail) | 2.5% Ultra Rare | 173 pts |
| Bronze | Butterfingers | Make 10 enemies drop their grenades | 2.7% Ultra Rare | 165 pts |
| Bronze | Trials and Tribulations | Solve the first Trial in Scotland in 10 moves or less | 3.1% Ultra Rare | 152 pts |
| Bronze | Hang Tough! | Destroy 10 vehicles while being dragged from the rope | 3.4% Ultra Rare | 144 pts |
| Bronze | Friends Forever! | Spawn 10 Sidekicks in Multiplayer | 4.3% Ultra Rare | 125 pts |
| Bronze | Charted! - Hard | Complete the game in hard mode | 4.3% Ultra Rare | 125 pts |
| Bronze | Medic! | Revive 10 Allies in Multiplayer | 5.4% Very Rare | 109 pts |
| Bronze | Glamour Shot | Take a photo of Sully | 5.5% Very Rare | 108 pts |
| Bronze | I Can See My House From Here! | Climb to the very top of the Clocktower in the City | 5.7% Very Rare | 106 pts |
| Bronze | Treasure Hunter | Find 50 treasures | 5.7% Very Rare | 106 pts |
| Bronze | Get in the Game | Complete 5 matches in Multiplayer | 7.8% Very Rare | 87 pts |
| Bronze | Boom County | Defeat 4 enemies with the same explosion (all explosive items and weapons apply) | 8.5% Very Rare | 83 pts |
| Bronze | Hitting a Brick Wall | Defeat 5 armored enemies with melee only | 8.6% Very Rare | 82 pts |
| Silver | Unstoppable! | Defeat 100 enemies in a row without dying in combat | 10.1% Rare | 112 pts |
| Bronze | Run-and-Gunner | Defeat 50 enemies from-the-hip or blind-firing | 10.2% Rare | 74 pts |
| Gold | Ludonarrative Dissonance | Defeat 1000 enemies | 11.9% Rare | 136 pts |
| Bronze | Cliffhanger | Pull 20 enemies over when hanging from a ledge | 14.3% Rare | 61 pts |
| Bronze | Continue the Adventure | Complete the Uncharted Multiplayer Introduction | 14.8% Rare | 60 pts |
| Bronze | Marco Polo Returns! | Play in the ocean near the sunken ship | 21.5% Uncommon | 48 pts |
| Bronze | Charted! - Moderate | Complete the game in moderate mode | 25.7% Uncommon | 43 pts |
| Bronze | Don't Feed the Animals | Play with the lemur in the market and let it steal your apple | 27% Uncommon | 42 pts |
| Bronze | Charted! - Light | Complete the game in light mode | 32.9% Uncommon | 37 pts |
| Bronze | Still Got It! | Hit all targets in the attic with the toy gun | 34.6% Uncommon | 36 pts |
| Bronze | Wingman | Perform 10 combo buddy takedowns | 36% Uncommon | 35 pts |
| Bronze | Charted! - Explorer | Complete the game in explorer mode | 36.4% Uncommon | 35 pts |
| Bronze | Shh Sleep Now | Stealth take-down 30 enemies | 44.8% Common | 31 pts |
| Bronze | You Have a Head for this Business | Defeat 50 enemies with headshots | 58.2% Common | 26 pts |
| Bronze | Take a Note | Find a Journal Note | 64.3% Common | 25 pts |
| Bronze | Jot This Down | Find a Journal Entry | 66.2% Common | 24 pts |
| Bronze | Stealth First Ask Questions Later | Stealth take-down 5 enemies | 66.9% Common | 24 pts |
| Bronze | Head of the Class! | Defeat 20 enemies with headshots | 68.5% Common | 24 pts |
| Bronze | First Treasure | Find a Treasure | 81.3% Common | 21 pts |