| Platinum | Raccoon City Native | Obtain all trophies. | 3.5% Ultra Rare | 566 pts |
| Silver | Minimalist | Clear the game without opening the item box. | 4.6% Ultra Rare | 180 pts |
| Bronze | Grim Reaper | Complete "The 4th Survivor" extra mode. | 5% Very Rare | 114 pts |
| Silver | Frugalist | Complete the game without using a recovery item. | 5.1% Very Rare | 169 pts |
| Bronze | Lore Explorer | Read all of the files. | 5.2% Very Rare | 112 pts |
| Silver | Complete Vermin Extermination | Destroy all Mr. Raccoons. | 5.4% Very Rare | 164 pts |
| Silver | A Small Carbon Footprint | Take 14000 steps or fewer in one playthrough. | 5.4% Very Rare | 164 pts |
| Bronze | Young Escapee | Escape the bedroom within 60 seconds during Sherry's segment. | 5.8% Very Rare | 104 pts |
| Gold | Hardcore College Student | Complete Claire's story on "Hardcore" game mode. | 6% Very Rare | 205 pts |
| Gold | Sizzling Scarlet Hero | Complete Claire's story on "Standard" or "Hardcore" with an S rank. | 6.2% Very Rare | 201 pts |
| Gold | Leon "S." Kennedy | Complete Leon's story on "Standard" or "Hardcore" with an S rank. | 6.3% Very Rare | 199 pts |
| Gold | Hardcore Rookie | Complete Leon's story on "Hardcore" game mode. | 6.4% Very Rare | 197 pts |
| Bronze | One Slick Super-spy | Use only the EMF Visualizer to complete Ada's gameplay segment. | 6.7% Very Rare | 96 pts |
| Bronze | Treasure Hunter | Using the photo hints, find 2 hidden items. | 14.5% Rare | 60 pts |
| Bronze | With Time to Spare | Defeat Stage 4 G with 4+ minutes left until detonation. | 17.7% Rare | 54 pts |
| Silver | Gotcha! | Defeat Stage 2 G using the crane only once. | 20.1% Uncommon | 74 pts |
| Silver | Broken Umbrella | Witness the true ending. | 20.5% Uncommon | 73 pts |
| Bronze | Zombie Roundup | Kill 3 enemies at once with a sub-weapon. | 20.6% Uncommon | 49 pts |
| Bronze | In the Blink of an Eye | Defeat Super Tyrant with 5+ minutes left until detonation. | 20.8% Uncommon | 49 pts |
| Silver | A Heroine Emerges | Complete Claire's story. | 26.7% Uncommon | 63 pts |
| Bronze | A Waist of Space | Expand inventory slots to max. | 28.1% Uncommon | 41 pts |
| Bronze | Hide and Seek | Complete Sherry's segment. | 29.1% Uncommon | 40 pts |
| Silver | Master of Unlocking | Open all of the safes and locks in the game. | 31.6% Uncommon | 57 pts |
| Silver | A Hero Emerges | Complete Leon's story. | 39.6% Uncommon | 50 pts |
| Bronze | Like Skeet Shooting | Shoot a zombie dog or a licker out of the air. | 40.8% Common | 32 pts |
| Bronze | Hack Complete | Complete Ada's segment. | 43.6% Common | 31 pts |
| Bronze | A Great Need for a Shower | Escape from the sewers. | 44.5% Common | 31 pts |
| Bronze | Keep Their Heads Ringin' | Paralyze a licker's sense of hearing. | 44.7% Common | 31 pts |
| Bronze | Hats Off! | Shoot Tyrant's hat off his head. | 44.8% Common | 31 pts |
| Bronze | Bon Appétit | Shoot the grenade you fed to an enemy. | 47.5% Common | 30 pts |
| Bronze | Don't Need No Stinkin' Gun | Defeat an enemy with a knife. | 47.8% Common | 29 pts |
| Bronze | Never-Ending Rain | Escape the police station. | 48.1% Common | 29 pts |
| Bronze | Vermin Extermination | Destroy a Mr. Raccoon. | 50.1% Common | 29 pts |
| Bronze | Path to the Goddess | Solve the Goddess Statue puzzle. | 58.4% Common | 26 pts |
| Bronze | A Vault-like Mind | Open a portable safe. | 63.1% Common | 25 pts |
| Bronze | Customizer | Customize a weapon. | 64.1% Common | 25 pts |
| Bronze | First Break-In | Open a dial safe. | 67.1% Common | 24 pts |
| Bronze | That'll Hold 'Em | Use Wooden Boards to board up a window. | 68.1% Common | 24 pts |
| Bronze | Hip to Add Squares | Increase your inventory slots. | 68.2% Common | 24 pts |
| Bronze | The Basics of Survival | Combine two items together. | 71.8% Common | 23 pts |
| Bronze | Eat This! | Counterattack with a sub-weapon. | 71.8% Common | 23 pts |
| Bronze | Welcome to the City of the Dead | Make it to the police station. | 83.7% Common | 21 pts |