| Platinum | The Final Frontier | Earn all Trophies in Dead Space™ 2 | 1.9% Ultra Rare | 2,449 pts |
| Gold | Hard to the Core | Complete the game on Hard Core setting | 2.1% Ultra Rare | 1,153 pts |
| Bronze | Elevator Action | Knock off every Tripod during the Elevator Sequence | 5.8% Very Rare | 313 pts |
| Gold | Mission Impossible | Complete the game on Zealot setting | 5.9% Very Rare | 621 pts |
| Bronze | Vacuum Cleaner | Decompress 20 Necromorphs without getting sucked out yourself | 6.9% Very Rare | 282 pts |
| Bronze | The Nanny | Kill 30 Crawlers without detonating them | 8.1% Very Rare | 257 pts |
| Bronze | The Sampler Platter | Kill a Necromorph with every Weapon in the game (single player only). | 8.7% Very Rare | 246 pts |
| Bronze | Fully Loaded | Simultaneously have four completely upgraded weapons | 10% Rare | 226 pts |
| Bronze | My Boom Stick | Kill 6 enemies at once with Line Gun's Alt-Fire (single player only) | 10.3% Rare | 222 pts |
| Bronze | Skewered in Space | Impale an enemy into a Decompression Window to cause it to blow out | 11% Rare | 214 pts |
| Bronze | Necro Flambé | Kill 50 enemies using the Flamethrower | 11.2% Rare | 211 pts |
| Bronze | C-Section | Knock down an enemy with Contact Beam Alt-Fire then kill it with Primary Fire before it stands up | 11.3% Rare | 210 pts |
| Bronze | It's a Trap! | Kill 20 enemies with Detonator Mines in a deployed state | 12.7% Rare | 196 pts |
| Bronze | Think Fast | Kill 30 Necromorphs with Kinesis objects | 13.4% Rare | 190 pts |
| Silver | Epic Dismemberment | Dismember 2,500 Necromorph Limbs (single player only) | 13.8% Rare | 280 pts |
| Bronze | ...And Stay Down | Kill 25 crawling enemies with Stomp (single player only) | 14.5% Rare | 181 pts |
| Bronze | Bouncing Betty | Kill a Cyst by catching its Mine and throwing it back | 15.2% Rare | 176 pts |
| Bronze | Peek a Boo! | Kill a Stalker with the Seeker Rifle while in Zoom Mode | 16.5% Rare | 167 pts |
| Bronze | Shock Therapy | Impale an enemy with the Javelin Gun and use its Alt-Fire to shock 3 others (single player only) | 17.5% Rare | 162 pts |
| Bronze | Fully Outfitted | Upgrade your RIG and Stasis completely | 17.6% Rare | 161 pts |
| Bronze | Lightspeed de Milo | Dismember the Lightspeed Boy Statue | 17.8% Rare | 160 pts |
| Bronze | Lawnmower Man | Kill 4 enemies with the same Ripper blade | 19.7% Rare | 151 pts |
| Silver | Collect Peng | Find the Peng treasure | 20% Uncommon | 224 pts |
| Bronze | Clean Cut | Sever all three tentacles of a Lurker with one Line Gun Primary Fire shot (single player only) | 21.7% Uncommon | 142 pts |
| Bronze | Picking favorites | Upgrade 1 Weapon completely | 25.8% Uncommon | 128 pts |
| Bronze | Frozen in Time | Kill 50 Necromorphs while they are in Stasis (single player only) | 28% Uncommon | 122 pts |
| Bronze | Going for Distance | Impale an enemy and make him fly through the air for 17 meters - it must stick to the surface | 30.6% Uncommon | 116 pts |
| Bronze | Brute Juke | Kill a Brute without taking damage | 37.1% Uncommon | 103 pts |
| Gold | The Fugitive | Escape the Facility | 37.4% Uncommon | 205 pts |
| Bronze | Made Us Whole | Complete the game on any difficulty setting | 37.4% Uncommon | 102 pts |
| Bronze | The Final Sacrifice | Destroy the Marker | 37.5% Uncommon | 102 pts |
| Bronze | Taste of your own Medicine | TK Impale a live Slasher to a surface using a Slasher's arm - it must stick to the surface | 40.8% Common | 97 pts |
| Bronze | Cross your Heart, Hope to Die | Survive the Eye Poke Machine | 41.4% Common | 96 pts |
| Bronze | Looking good | Purchase the Advanced Suit | 41.7% Common | 96 pts |
| Bronze | Knock Knock | Complete the Drill Ride | 43% Common | 94 pts |
| Bronze | The Librarian | Collect 100 logs | 43.6% Common | 93 pts |
| Bronze | Operation! | Snare the Shard with the Ishimura | 44.6% Common | 92 pts |
| Bronze | Hornet's Nest | Destroy the Tripod Nest | 47.2% Common | 89 pts |
| Silver | The Electrician | Collect 10 Semiconductors | 47.3% Common | 133 pts |
| Silver | The Engineer | Collect 10 Schematics | 47.6% Common | 133 pts |
| Bronze | Powered Up | Complete the Solar Array Puzzle | 51.7% Common | 84 pts |
| Bronze | Shut Down | Defeat the AI | 52.8% Common | 83 pts |
| Bronze | The Graduate | Win the fight at the School | 55.1% Common | 81 pts |
| Bronze | Torment Me No More | Kill the Tormenter | 60.7% Common | 77 pts |
| Bronze | Clever Girls | Survive your first encounter with Stalkers | 63.8% Common | 74 pts |
| Bronze | Romper Stomper | Stomp 10 Containers | 65.2% Common | 73 pts |
| Bronze | One Small Step | Get through the first Zero-G area | 68.9% Common | 71 pts |
| Bronze | First Aid | Use Quick Heal ten times (single player only) | 70.3% Common | 70 pts |
| Bronze | Derailed | Survive the Train Sequence | 72.1% Common | 69 pts |
| Bronze | Patient on the Loose | Get your first Suit | 78.6% Common | 66 pts |
| Bronze | Shoot the Limbs! | Dismember 25 Necromorph Limbs (single player only) | 84.6% Common | 63 pts |