| Platinum | Eternal One | Obtain all other Trophies. | 0.9% Ultra Rare | 3,835 pts |
| Gold | Who Needs Relics? | Beat the game with a single relic. | 1.3% Ultra Rare | 1,538 pts |
| Silver | Common Sense | Beat the game with a deck containing no uncommons or rares. | 1.5% Ultra Rare | 1,058 pts |
| Silver | Minimalist | Beat the game with a 5 card deck or smaller. | 1.5% Ultra Rare | 1,058 pts |
| Silver | Focused | Have 25 or more Focus during combat. | 1.7% Ultra Rare | 982 pts |
| Gold | Ascend 20 | Complete Ascension Level 20. | 1.8% Ultra Rare | 1,265 pts |
| Silver | Speed Climber | Beat the game in under 20 minutes. | 1.9% Ultra Rare | 919 pts |
| Silver | Neon | Channel 9 Plasma in a single turn. | 1.9% Ultra Rare | 919 pts |
| Silver | You Are Nothing | Defeat a boss on turn 1. | 2.8% Ultra Rare | 728 pts |
| Silver | Ooh Donut! | Finish Donu with a Feed. | 3.1% Ultra Rare | 685 pts |
| Silver | Ascend 10 | Complete Ascension Level 10. | 3.8% Ultra Rare | 606 pts |
| Silver | The Transient | Defeat the Transient before it fades away. | 3.8% Ultra Rare | 606 pts |
| Silver | Barricaded | Have 999 Block during combat. | 4% Ultra Rare | 588 pts |
| Silver | The End? | Complete the Ending with the Ironclad, Silent, and Defect. | 4.2% Ultra Rare | 571 pts |
| Bronze | Purity | Have 3 or fewer cards in hand, draw, and discard pile combined. | 5% Very Rare | 343 pts |
| Silver | Sapphire+ | Complete the Ending with the Defect. | 5.8% Very Rare | 470 pts |
| Silver | Ruby+ | Complete the Ending with the Ironclad. | 6.7% Very Rare | 431 pts |
| Silver | Infinity | Play 25 cards in a single turn. | 7.1% Very Rare | 416 pts |
| Silver | Emerald+ | Complete the Ending with the Silent. | 7.2% Very Rare | 413 pts |
| Silver | Jaxxed | Have 50 or more Strength during combat. | 9.2% Very Rare | 357 pts |
| Bronze | My Lucky Day | Win a Daily Climb. | 13.3% Rare | 191 pts |
| Silver | Ninja | Play 10 Shivs in a single turn. | 14.5% Rare | 271 pts |
| Bronze | Powerful | Have 10 or more buffs during combat. | 14.7% Rare | 179 pts |
| Bronze | Catalyst | Apply 99 or more Poison on a single enemy. | 15.6% Rare | 173 pts |
| Bronze | Impervious | Have 99 or more Block during combat. | 16.7% Rare | 166 pts |
| Bronze | Sapphire | Beat the game with the Defect. | 25% Uncommon | 130 pts |
| Bronze | The Time Eater | Defeated the Time Eater. | 25.3% Uncommon | 130 pts |
| Bronze | Emerald | Beat the game with the Silent. | 28.1% Uncommon | 122 pts |
| Bronze | The Crow | Defeated the Awakened One. | 30.1% Uncommon | 117 pts |
| Bronze | The Shapes | Defeated Donu & Deca. | 30.3% Uncommon | 116 pts |
| Bronze | Plague | Defeat 3 enemies with Poison in a single combat. | 30.4% Uncommon | 116 pts |
| Bronze | Perfect | Defeat a boss without taking any damage. | 30.9% Uncommon | 115 pts |
| Bronze | Ruby | Beat the game with the Ironclad. | 31.7% Uncommon | 113 pts |
| Bronze | Come At Me | Win a combat without playing an Attack. | 32.6% Uncommon | 111 pts |
| Bronze | Adrenaline | Have 9 Energy during a single turn of combat. | 36% Uncommon | 105 pts |
| Bronze | Shrug It Off | Win a battle with 1 HP remaining. | 37.8% Uncommon | 102 pts |
| Bronze | The Collector | Defeated the Collector. | 38.7% Uncommon | 100 pts |
| Bronze | The Pact | Exhaust 20 cards in a single combat. | 38.8% Uncommon | 100 pts |
| Bronze | Ascend 0 | Unlock Ascension mode. | 39.4% Uncommon | 99 pts |
| Bronze | The Automaton | Defeated the Bronze Automaton. | 40.7% Common | 97 pts |
| Bronze | The Champion | Defeated the Champ. | 45.9% Common | 91 pts |
| Bronze | The Boss | Defeated the Slime Boss. | 55.3% Common | 81 pts |
| Bronze | The Ghost | Defeated Hexaghost. | 59.6% Common | 77 pts |
| Bronze | The Guardian | Defeated the Guardian. | 65.6% Common | 73 pts |