| Platinum | Platinum Columbia | Acquire all other trophies | 1.5% Ultra Rare | 941 pts |
| Gold | Scavenger Hunt | Completed the Main Campaign in 1999 Mode without purchasing anything from a Dollar Bill machine. | 1.8% Ultra Rare | 422 pts |
| Silver | Auld Lang Syne | Completed the Main Campaign on 1999 Mode. | 2% Ultra Rare | 297 pts |
| Bronze | Sightseer | In the Main Campaign, used all telescopes and Kinetoscopes in the game. | 2.4% Ultra Rare | 177 pts |
| Silver | Lost Weekend | In the Main Campaign, killed 5 enemies while you are drunk. | 2.5% Ultra Rare | 260 pts |
| Silver | Eavesdropper | In the Main Campaign, collected every Voxophone. | 2.8% Ultra Rare | 243 pts |
| Bronze | Infused with Greatness | In the Main Campaign, collected every Infusion upgrade in a single game. | 3.4% Ultra Rare | 144 pts |
| Silver | Combination Shock | In the Main Campaign, performed all 8 of the Vigor combinations. | 3.5% Ultra Rare | 212 pts |
| Bronze | On the Fly | In the Main Campaign, killed 30 enemies while riding a Sky-Line. | 3.9% Ultra Rare | 133 pts |
| Silver | Stone Cold Pinkerton | Completed the Main Campaign on Hard difficulty or above. | 4.5% Ultra Rare | 183 pts |
| Silver | Bon Voyage | In the Main Campaign, killed 20 enemies by knocking them off Columbia. | 4.9% Ultra Rare | 173 pts |
| Silver | Bolt From the Blue | In the Main Campaign, killed 5 enemies with a headshot while riding a Sky-Line. | 5.9% Very Rare | 155 pts |
| Silver | Mind Over Matter | In the Main Campaign, killed 20 enemies using Possessed machines. | 6.5% Very Rare | 146 pts |
| Silver | Skeet Shoot | In the Main Campaign, killed 5 enemies while they are falling. | 6.5% Very Rare | 146 pts |
| Bronze | Heartbreaker | In the Main Campaign, killed a Handyman by only shooting his heart. | 6.6% Very Rare | 97 pts |
| Bronze | Raising the Bar | In the Main Campaign, upgraded one attribute (Health, Shield, or Salts) to its maximum level. | 11.4% Rare | 70 pts |
| Bronze | Seasoned to Taste | In the Main Campaign, killed 30 enemies with the Peppermill Crank Gun. | 15.3% Rare | 58 pts |
| Bronze | Aerial Assassin | In the Main Campaign, killed 20 enemies with a Sky-Line Strike. | 15.3% Rare | 58 pts |
| Silver | Strange Bedfellows | In the Main Campaign, killed 20 enemies using allies brought in through a Tear. | 17.6% Rare | 81 pts |
| Bronze | Here Little Piggy | In the Main Campaign, killed 30 enemies with the Founder Pig Volley Gun or Vox Hail Fire. | 18.5% Rare | 52 pts |
| Bronze | Industrial Accident | In the Main Campaign, killed 20 enemies with a Sky-Hook Execution. | 19.3% Rare | 51 pts |
| Silver | More for Your Money | In the Main Campaign, lured 3 enemies into a single Vigor trap 5 times. | 19.7% Rare | 75 pts |
| Bronze | Passionately Reciprocated | In the Main Campaign, killed 150 enemies with the Founder Triple R Machine Gun or Vox Repeater. | 22.1% Uncommon | 47 pts |
| Silver | Hazard Pay | In the Main Campaign, killed 10 enemies by utilizing environmental hazards. | 22.7% Uncommon | 69 pts |
| Bronze | Saw the Elephant | Completed the Main Campaign on Normal difficulty or above. | 23.3% Uncommon | 45 pts |
| Bronze | Loose Cannon | In the Main Campaign, killed 25 enemies with the Paddywhacker Hand Cannon. | 25.6% Uncommon | 43 pts |
| Bronze | Master of Pyrotechnics | In the Main Campaign, killed 20 enemies with the Barnstormer RPG. | 26.1% Uncommon | 42 pts |
| Bronze | Big Game Hunter | In the Main Campaign, killed 100 enemies with the Founder Huntsman Carbine or Vox Burstgun. | 26.8% Uncommon | 42 pts |
| Bronze | Well Rounded | In the Main Campaign, used all 8 Vigors against enemies. | 29.1% Uncommon | 40 pts |
| Bronze | On a Clear Day... | In the Main Campaign, killed 30 enemies with the Bird's Eye Sniper Rifle. | 30.4% Uncommon | 39 pts |
| Bronze | Grand Largesse | In the Main Campaign, spent $10,000 at the vending machines of Columbia. | 31% Uncommon | 38 pts |
| Bronze | Kitted Out | In the Main Campaign, fully upgraded one weapon and one Vigor. | 31% Uncommon | 38 pts |
| Bronze | The Bird or The Cage | Completed The Hand of the Prophet. | 33.5% Uncommon | 36 pts |
| Bronze | Tin Soldier | Completed the Main Campaign on Easy difficulty or above. | 33.5% Uncommon | 36 pts |
| Bronze | Should Auld Acquaintance... | Unlocked 1999 Mode. | 33.9% Uncommon | 36 pts |
| Bronze | Street Sweeper | In the Main Campaign, killed 50 enemies with the Founder China Broom Shotgun or Vox Heater. | 34.9% Uncommon | 36 pts |
| Silver | The Roguish Type | In the Main Campaign, used Elizabeth to pick 30 locks. | 38.7% Uncommon | 50 pts |
| Bronze | Higher Learning | Completed Comstock House. | 38.7% Uncommon | 33 pts |
| Bronze | Blood in the Streets | Completed Emporia. | 40% Common | 33 pts |
| Bronze | Vigorous Opposition | In the Main Campaign, killed 75 enemies either with a Vigor or while the enemy is under the effects of a Vigor. | 45.9% Common | 30 pts |
| Bronze | Working Class Hero | In the Main Campaign, completed the Factory. | 46.6% Common | 30 pts |
| Bronze | Tear 'em a New One | In the Main Campaign, opened 30 Tears. | 47.6% Common | 30 pts |
| Bronze | Armed Revolt | Assisted the gunsmith. | 48.4% Common | 29 pts |
| Silver | Coins in the Cushion | In the Main Campaign, looted 200 containers. | 49.2% Common | 43 pts |
| Bronze | David & Goliath | In the Main Campaign, killed 20 "Heavy Hitter" enemies. | 49.8% Common | 29 pts |
| Silver | Dress for Success | In the Main Campaign, equipped a piece of Gear in all four slots. | 51.2% Common | 42 pts |
| Bronze | First Class Ticket | In the Main Campaign, boarded The First Lady. | 55.2% Common | 27 pts |
| Bronze | Shock Tactics | Retrieved Shock Jockey. | 58.4% Common | 26 pts |
| Bronze | A Real Pistol | In the Main Campaign, killed 25 enemies with the Broadsider Pistol. | 65% Common | 25 pts |
| Bronze | Welcome to Monument Island | Reached Monument Island. | 68.1% Common | 24 pts |
| Bronze | Written in the Clouds | In the Main Campaign, completed Lighthouse. | 92.8% Common | 20 pts |