| Platinum | Hyperthymesiac | Earn every trophy in the game | 11.3% Rare | 280 pts |
| Silver | Storyteller | Achieve all 6 of the game's endings | 11.5% Rare | 104 pts |
| Silver | Antiquarian | Complete your Artifacts Checklist 100% | 11.5% Rare | 104 pts |
| Bronze | Saint | Achieve the LIGHT ending in every Forsaken Room | 11.5% Rare | 69 pts |
| Bronze | Sinner | Achieve the BLOOD ending in every Forsaken Room | 11.5% Rare | 69 pts |
| Bronze | Beat Maniac | Earn a 30 or greater timed hit combo | 11.5% Rare | 69 pts |
| Silver | Couch Potato | Complete your Broadcasts Checklist 100% | 11.6% Rare | 103 pts |
| Bronze | Choice Meat | Defeat 25 Butchers with the Great Cleaver | 11.6% Rare | 69 pts |
| Bronze | Light Heal Us | Use Heal Us Karma Ability to restore 50% or more health each to 3 players (multiplayer) | 11.6% Rare | 69 pts |
| Bronze | Hammer Time | Defeat 25 Bogeymen with the Bogeyman's Hammer | 11.6% Rare | 69 pts |
| Bronze | Comatose | Reach Zone 100 | 11.6% Rare | 69 pts |
| Bronze | Master | Level up to LVL 50 | 11.6% Rare | 69 pts |
| Bronze | Agnostic | Achieve the NEUTRAL ending in every Forsaken Room | 11.6% Rare | 69 pts |
| Bronze | Power Repeller | Use Push Force Power Move to knock 8 or more enemies back at once | 11.6% Rare | 69 pts |
| Bronze | Light Heal You | Use Heal You Karma Ability to restore 50% or more health to a friend (multiplayer) | 11.7% Rare | 69 pts |
| Bronze | Pyramid Scheme | Defeat 25 Pyramid Heads with the Great Knife | 11.7% Rare | 69 pts |
| Bronze | Wingman | Defeat any Guardian with all four players still alive (multiplayer) | 11.8% Rare | 68 pts |
| Bronze | Blood Burn | Use Blood Burn Karma Ability to damage 4 different enemy types at once | 11.8% Rare | 68 pts |
| Bronze | Blood Beam | Use Blood Beam Karma Ability on 5 or more enemies at once | 11.8% Rare | 68 pts |
| Bronze | Executioner | Perform a timed execution on 10 enemies in one Zone | 11.8% Rare | 68 pts |
| Silver | Arms Dealer | Complete your Weapons Checklist 100% | 11.9% Rare | 102 pts |
| Bronze | Power Savior | Use Health Siphon Power Move to bring a dying friend back to life (multiplayer) | 11.9% Rare | 68 pts |
| Silver | Veterinarian | Complete your Bestiary Checklist 100% | 12% Rare | 101 pts |
| Bronze | Blacksmith | Level up 10 different weapons | 12% Rare | 68 pts |
| Bronze | Deep Sleeper | Reach Zone 50 | 12% Rare | 68 pts |
| Bronze | Medic | Drop a health pack after a friend requests one (multiplayer) | 12.1% Rare | 67 pts |
| Silver | Librarian | Complete your Notes Checklist 100% | 12.3% Rare | 100 pts |
| Bronze | Power Inverter | Use Karma Flip Power Move to flip 8 or more enemies at once | 12.3% Rare | 67 pts |
| Bronze | Tommfoolery | Perform every in-game VO clip for one character | 12.4% Rare | 66 pts |
| Silver | Emissary | Complete Valtiel's missions in Zones 1 through 21 | 12.5% Rare | 99 pts |
| Bronze | Apprentice | Level up to LVL 25 | 12.5% Rare | 66 pts |
| Bronze | Moneybags | Spend over 250,000 MR in Howard's shop | 12.6% Rare | 66 pts |
| Bronze | Power Flasher | Use Flash Burst Power Move to kill 5 or more stunned enemies in a row | 12.7% Rare | 65 pts |
| Bronze | Sugar High | Complete a Zone without stopping for more than 30 seconds total | 12.9% Rare | 65 pts |
| Bronze | Power Breaker | Use Weapon Breaker Power Move with a weapon that's about to shatter | 12.9% Rare | 65 pts |
| Bronze | Blood Barrage | Use Blood Barrage Karma Ability to kill 5 or more enemies | 13.1% Rare | 64 pts |
| Silver | Architect | Complete your Rooms Checklist 100% | 13.3% Rare | 95 pts |
| Bronze | Bouncer | Complete a Zone using only your fists (no weapons) | 13.7% Rare | 62 pts |
| Bronze | Beast Master | Defeat any Guardian without taking damage | 13.7% Rare | 62 pts |
| Bronze | Power Charger | Use Charge Tackle Power Move to knock one enemy into another | 14.1% Rare | 61 pts |
| Gold | Author | Defeat the Steel Guardian and complete the game | 14.6% Rare | 120 pts |
| Bronze | Phlebotomist | Defeat the Blood Guardian | 15.2% Rare | 59 pts |
| Bronze | Miner | Defeat the Earth Guardian | 16.2% Rare | 56 pts |
| Bronze | Power Switcher | Use 360 Attack Power Move to strike 4 or more enemies at once | 16.5% Rare | 56 pts |
| Bronze | Plumber | Defeat the Water Guardian | 17.5% Rare | 54 pts |
| Bronze | Light Heal Me | Use Heal Me Karma Ability to restore 25% or more health | 19.1% Rare | 51 pts |
| Bronze | Klutz | Trigger every kind of trap in the game | 19.8% Rare | 50 pts |
| Bronze | Sandman | Defeat the Light Guardian | 21% Uncommon | 48 pts |
| Bronze | Brainiac | Complete any 5 puzzles without using the hint lever | 22.3% Uncommon | 47 pts |
| Bronze | Disorderly Conduct | Defeat 25 Nurses with the Steel Pipe | 26.7% Uncommon | 42 pts |
| Bronze | Bleeder | Lose more than 400% health in one Zone without dying | 27.4% Uncommon | 41 pts |
| Bronze | Lumberjack | Defeat the Wood Guardian | 27.8% Uncommon | 41 pts |
| Bronze | Ninja | Complete a Zone without turning on your flashlight | 31.9% Uncommon | 38 pts |
| Bronze | Fireman | Defeat the Fire Guardian | 41.6% Common | 32 pts |
| Bronze | Consumer | Make a purchase in Howard's shop | 58.1% Common | 26 pts |
| Bronze | Light Napper | Complete Zone 1 | 63.2% Common | 25 pts |
| Bronze | Novice | Level up to LVL 2 | 70.6% Common | 23 pts |
| Bronze | Creator | Create a character | 91.9% Common | 20 pts |