| Platinum | The Beyonder | Collected all other Marvel Heroes Omega trophies. | 0.1% Ultra Rare | 4,777 pts |
| Silver | Myth No More | Fully upgrade a Legendary Item. | 0.1% Ultra Rare | 1,791 pts |
| Gold | There and Back Again | Prestige any Hero twice. | 0.3% Ultra Rare | 1,236 pts |
| Silver | Treasure Hunting | Explore all of the Treasure Rooms in each chapter of Story Missions. | 0.3% Ultra Rare | 927 pts |
| Silver | Mark II | Apply a Modification to an Artifact. | 0.3% Ultra Rare | 927 pts |
| Silver | Hero For Hire | Open 50 Bounty Chests in Operations. | 0.4% Ultra Rare | 780 pts |
| Gold | Super Team | Get Five Heroes to Level 60. | 0.5% Ultra Rare | 909 pts |
| Silver | Special Ops | Complete 14 Different Operations. | 0.5% Ultra Rare | 682 pts |
| Bronze | Gazillionaire | Loot 1,000,000 Credits. | 0.5% Ultra Rare | 455 pts |
| Bronze | Part-Time Hero | Rescue 100 civilians in Midtown Patrol. | 0.5% Ultra Rare | 455 pts |
| Silver | Living Legend | Complete 50 Legendary Quests. | 0.6% Ultra Rare | 611 pts |
| Silver | Back to Basics | Prestige any Hero. | 0.7% Ultra Rare | 557 pts |
| Gold | Strongest One There Is | Complete the Cosmic Trial with any hero. | 0.8% Ultra Rare | 686 pts |
| Silver | The Vault | Loot 100 Artifacts. | 0.8% Ultra Rare | 514 pts |
| Silver | Going for Gold | Loot a Cosmic Medallion. | 1% Ultra Rare | 450 pts |
| Silver | Rounding Up Relics | Collect any 100 Relics of the same type. | 1.2% Ultra Rare | 403 pts |
| Silver | Next Level Crafting | Level any vendor to level 10. | 1.3% Ultra Rare | 384 pts |
| Bronze | Targeted Frustration | Defeat a Training Room Target Dummy. | 1.4% Ultra Rare | 245 pts |
| Silver | Cleaning Up The Streets | Defeat 150 Super Villains in Midtown Manhattan. | 1.6% Ultra Rare | 339 pts |
| Bronze | Mobile Command Center | Visit Six Different Headquarters. | 1.8% Ultra Rare | 211 pts |
| Silver | If They Be Worthy... | Complete the Super Heroic Trial with any hero. | 1.9% Ultra Rare | 306 pts |
| Silver | High Noon | Defeat 7 Different Super Villains in their Showdowns. | 2.2% Ultra Rare | 280 pts |
| Silver | All In A Day's Work | Complete 24 different Alerts in Story missions. | 2.3% Ultra Rare | 273 pts |
| Silver | Super Hero | Reach level 60 with any hero. | 2.6% Ultra Rare | 254 pts |
| Silver | Throne of Deceit | Complete Chapter 9 in Story Mode. | 3.1% Ultra Rare | 228 pts |
| Bronze | A Doomed World | Defeat Doctor Doom in Chapter 8. | 3.6% Ultra Rare | 139 pts |
| Bronze | Duped! | Find and Defeat a Cosmic Doop. | 3.9% Ultra Rare | 133 pts |
| Bronze | Savage Safari | Defeat Mister Sinister in Chapter 7. | 4.9% Ultra Rare | 116 pts |
| Bronze | Stryker Under Siege | Defeat Magneto in Chapter 6. | 5.6% Very Rare | 107 pts |
| Bronze | Purification Crusade | Defeat Juggernaut in Chapter 5. | 6.4% Very Rare | 98 pts |
| Bronze | Topple the Kingpin | Defeat The Kingpin in Chapter 4. | 7.5% Very Rare | 90 pts |
| Bronze | Meet in Madripoor | Defeat Elektra in Chapter 3. | 9.8% Very Rare | 76 pts |
| Bronze | Pursuing the Hood | Defeat The Hood in Chapter 2. | 16.2% Rare | 56 pts |
| Bronze | Cleaning Up the Kitchen | Defeat Doctor Octopus in Chapter 1. | 28.4% Uncommon | 40 pts |
| Bronze | Trouble at the Raft | Defeat Green Goblin in the Prologue. | 61.3% Common | 25 pts |