| Platinum | Fully Evolved | Unlock all other Trophies | 1.1% Ultra Rare | 1,133 pts |
| Gold | Scenario Master | Score 3 biohazards in every Official scenario | 1.2% Ultra Rare | 538 pts |
| Silver | Film Fanatic | Recreate the setting of the Dawn of the Planet of the Apes film | 1.3% Ultra Rare | 384 pts |
| Silver | Not Another Zombie Game | Win a game with the Necroa Virus without making a single zombie | 1.5% Ultra Rare | 353 pts |
| Gold | Disease Master | Complete all disease types on mega-brutal difficulty | 1.7% Ultra Rare | 436 pts |
| Silver | Breathe Deep | Infect the Chernobyl research team | 1.7% Ultra Rare | 327 pts |
| Silver | Plague in Space | Infect astronauts before they launch a space mission | 1.7% Ultra Rare | 327 pts |
| Silver | Revenge of Osiris | Invalidate the knowledge of the pharaohs | 1.7% Ultra Rare | 327 pts |
| Silver | Russian Nuclear Retaliation | Make the USA nuke Russia | 2% Ultra Rare | 297 pts |
| Silver | The Future is Bright | End the game with apes and humans living together peacefully | 2.3% Ultra Rare | 273 pts |
| Bronze | Use your head | Discover the Cranial Dispersion combo | 2.5% Ultra Rare | 173 pts |
| Bronze | Boomer | Discover the Boomer combo | 3% Ultra Rare | 155 pts |
| Bronze | Is it a bird? | Discover the Vampire Bat combo | 3.4% Ultra Rare | 144 pts |
| Bronze | Patient Who? | Stop the CDC finding Patient Zero | 3.7% Ultra Rare | 137 pts |
| Bronze | Insane Bolt | Sprint to victory and set a world record by winning the game with Bacteria in under 365 days | 3.7% Ultra Rare | 137 pts |
| Bronze | Not Necroa | Discover the Zombie Panic Combo | 4% Ultra Rare | 131 pts |
| Bronze | Ultimate Christmas | Discover the Ultimate Christmas Combo | 4.4% Ultra Rare | 123 pts |
| Bronze | Tank | Discover the Tank combo | 4.9% Ultra Rare | 116 pts |
| Bronze | Tasty | Discover the Bath Time combo | 5% Very Rare | 114 pts |
| Bronze | Like flies round… | Discover the Fly Magnet Combo | 5.2% Very Rare | 112 pts |
| Silver | Unlock Cheatmodes | Unlock the cheats by winning a game on Normal for ALL disease types | 5.9% Very Rare | 155 pts |
| Bronze | Walking Contradiction | Discover the Walking Contradiction combo | 6.5% Very Rare | 98 pts |
| Bronze | Blind Genius | Discover the Blind Genius Combo | 6.7% Very Rare | 96 pts |
| Bronze | Not Just a Pretty Face | Make every ape in the world intelligent | 7.1% Very Rare | 93 pts |
| Bronze | Rude Awakening | Discover the Rude Awakening Combo | 7.6% Very Rare | 89 pts |
| Bronze | Spitter | Discover the Spitter combo | 8.2% Very Rare | 85 pts |
| Bronze | Jaws | Discover the Blood in the Air combo | 10% Rare | 75 pts |
| Bronze | Do it like they do | Discover the Discovery Channel Combo | 10.2% Rare | 74 pts |
| Bronze | Oink oink | Discover the Swineflu Combo | 11.3% Rare | 70 pts |
| Bronze | Runner | Discover the Runner combo | 11.5% Rare | 69 pts |
| Bronze | Bio-Weapon Victory | Win a game with Bio-Weapon on Normal Difficulty or higher | 11.7% Rare | 69 pts |
| Bronze | Ape's Creed | Discover the Assassin Combo | 12.3% Rare | 67 pts |
| Bronze | Red Ape Redemption | Discover the Red Ape Redemption Combo | 12.9% Rare | 65 pts |
| Bronze | Nano-Virus Victory | Win a game with Nano-Virus on Normal Difficulty or higher | 13.5% Rare | 63 pts |
| Bronze | Peer Pressure | Have your plague discovered after riots force a government investigation | 15.5% Rare | 58 pts |
| Bronze | Assuming Direct Control | Win a game by enslaving humanity with the Neurax Worm | 16% Rare | 57 pts |
| Bronze | The Glorious Dead | Win a game with the Necroa Virus | 18.1% Rare | 53 pts |
| Bronze | Worm Food | Win a game by eradicating humanity with the Neurax Worm | 21.2% Uncommon | 48 pts |
| Bronze | Prion Victory | Win a game with Prion on Normal Difficulty or higher | 23% Uncommon | 46 pts |
| Bronze | Parasite Victory | Win a game with Parasite on Normal Difficulty or higher | 24.7% Uncommon | 44 pts |
| Bronze | Brown Streets | Discover the Public Defecation combo | 25.4% Uncommon | 43 pts |
| Bronze | Neurax Worm Victory | Win a game with Neurax Worm on Normal Difficulty or higher | 26.2% Uncommon | 42 pts |
| Bronze | Fungus Victory | Win a game with Fungus on Normal Difficulty or higher | 28.8% Uncommon | 40 pts |
| Bronze | Virus Victory | Win a game with Virus on Normal Difficulty or higher | 44.2% Common | 31 pts |
| Bronze | Red Rain | Discover the Profuse Bleeding combo | 46.3% Common | 30 pts |
| Silver | STALKERs delight | Cause a nuclear meltdown | 47.2% Common | 45 pts |
| Bronze | Uh Oh | Discover the Oops symptom combo | 54.9% Common | 27 pts |
| Bronze | Bacteria Victory | Win a game with Bacteria on Normal Difficulty or higher | 55.5% Common | 27 pts |
| Bronze | Olympic Spoiler | Help the Olympics go viral in the UK | 56.7% Common | 27 pts |
| Bronze | Long Shot | Discover the Projectile Vomiting combo | 67.5% Common | 24 pts |
| Bronze | Brainzzzz | Discover the Waking Dead combo | 70.9% Common | 23 pts |
| Bronze | RMS Watch List | Get your Plague on the RMS Watch List | 91.8% Common | 20 pts |